Bioactive Small Molecules
Cayman Chemical ANTIBODY JWH 424 25mg
A soluble adenylyl cyclase inhibitor (IC50 3.3 nM) selective for sAC over AC1 AC2 AC5 AC8 and AC9 at 100 nM a panel of 322 kinases (IC50s >1000 nM for all) and 46 other targets including GPCRs nuclear receptors and ion channels (RC50s >9 UM for all) inhibits capacitation-induced cAMP accumulation in isolated mouse and human sperm at 5 UM reduces sodium bicarbonate-induced increases in mouse and human sperm beat frequency at 5 UM induces temporary infertility in male mice without affecting mating behavior after a single dose of 50 mg/kg
Medchemexpress LLC NADPH Oxidase 4 Antibody | 100 UL
NADPH Oxidase 4 Antibody is a rabbit-derived, non-conjugated IgG polyclonal antibody targeting NADPH Oxidase 4. It reacts with human, mouse, and rat. This antibody is for research use only. The NADPH Oxidase 4 gene encodes a member of the NOX-family of enzymes, acting as an oxygen sensor that catalyzes the reduction of molecular oxygen to reactive oxygen species (ROS). These ROS are involved in signal transduction, cell differentiation, and tumor cell growth.
- Rabbit-derived, non-conjugated IgG polyclonal antibody
- Targets NADPH Oxidase 4
- Reacts with human, mouse, and rat
- Predicted and observed band size: 67 kDa
- Affinity purified
- Liquid appearance
- Research use only
- Applications: WB, IHC-P, ICC/IF, IP
- Stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
![Medchemexpress LLC 4-[3-[(3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]benzamide | 824983-94-0 | 99.9% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230204.png-250.jpg)
Medchemexpress LLC 4-[3-[(3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]benzamide | 824983-94-0 | 99.9% | 100 MG
FEN1-IN-2 is a small-molecule inhibitor of flap endonuclease 1 (FEN1) reported to have nanomolar potency and used in biochemical and cellular studies of DNA repair pathways.
- Nanomolar potency against FEN1 (IC50 3 nM).
- Activity against XPG (IC50 226 nM).
- High purity (99.9% by HPLC).
- Molecular formula C20H15N3O4S and molecular weight 393.42 g/mol.
- Available in multiple solid pack sizes and as a 10 mM solution in DMSO.
Cayman Chemical RF9, Purity: ≥98%, CAS: 876310-60-0, 10 mg
An NPFF receptor antagonist; binds to human NPFF1 and NPFF2 receptors (Kis = 58 and 75 nM, respectively); selective for NPFF1 and NPFF2 receptors over NPY receptor Y1, GPR10, GPR54, GPR103, ORL-1, and μ-, δ-, and κ-opioid receptors at 10 μM; inhibits NPFF-induced [35S]GTPγS binding to the NPFF2 receptor at 7.5 μM; reverses NPVF-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing the human NPFF1 receptor (EC50 = 4.7 μM); inhibits NPFF-induced increases in mean arterial pressure and heart rate in rats at 10 μg, i.c.v.; prevents heroin-induced delayed hyperalgesia and associated tolerance in rats at 0.1 mg/kg, s.c.
Medchemexpress LLC DAPTA (D-Ala-peptide T-amide; Adaptavir) | 106362-34-9 | 98.9% | 856.88 | 5 MG
DAPTA is a synthetic peptide that functions as a viral entry inhibitor by selectively targeting CCR5, exhibiting potent anti-HIV activities.
- Inhibits HIV-1 replication in monocytes/macrophages by >90% at 1 nM.
- Blocks HIV entry and prevents HIV-1 infection.
- Reduces CCR5 mAb binding in human primary macrophages.
- Potently blocks R5 gp120-mediated neuronal apoptosis.
- More potent in preventing neuronal apoptosis than the CCR5 antagonist TAK-779.
- Potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
- Blocks formation of the gp120/sCD4 complex with CCR5 at 1 nM.
- Inhibits the binding of gp120BaL/sCD4 to CCR5 (Cf2Th/synR5) cells with IC50 of 55 +/- 0.08 pM.
Medchemexpress LLC Uridine 5'-diphosphate (sodium salt) | 21931-53-3 | 98.0% | 500 MG
Uridine 5'-diphosphate sodium salt is a potent and selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). This endogenous metabolite catalyzes the glucuronidation of a wide array of substrates and is utilized in nucleic acid (RNA) biosynthesis.
- Potent and selective P2Y6 receptor native agonist.
- Potent P2Y14 antagonist.
- Catalyzes glucuronidation of various substrates.
- Utilized in nucleic acid (RNA) biosynthesis.
Medchemexpress LLC NFAT Inhibitor-1 (VIVIT peptide) | 249537-73-3 | 99.9% | 1683.93 | 25 MG
NFAT Inhibitor-1 (VIVIT peptide) is a potent inhibitor of nuclear factor of activated T-cells (NFAT). It selectively inhibits calcineurin-mediated dephosphorylation of NFAT, making it suitable for research applications.
- Selectively inhibits calcineurin-mediated dephosphorylation of NFAT
- Significantly inhibits nuclear translocation of NFATc1
- Long-term treatment inhibits cytoplasmic levels of cathepsin K, TRAP, and MMP-9
- Inhibits protein expression of NFATC2 in hLESCs
- Inhibits the effect of WNT16b on cell proliferation in hLESCs
- Significantly inhibits expression of WNT16b-promoting cell proliferation marker Ki67 and the putative hLESC marker ΔNp63α in hLESCs
Cayman Chemical Eganelisib, Purity: ≥98%, CAS: 1693758-51-8, 5 mg
An inhibitor of PI3Kγ (IC50s = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively); selective for PI3Kγ over a panel of 468 mutant and nonmutant protein and lipid kinases and a panel of G protein-coupled receptors, ion channels, and transporters at 10 µM; inhibits migration of BMDMs (IC50 = 85 nM); sensitizes doxorubicin-resistant SW620/Ad300 cells to P-gp substrates, such as paclitaxel (IC50s = 710 and 6.7 nM for paclitaxel alone and in combination with IPI-549, respectively); enhances the tumor growth reduction of paclitaxel in an SW620/Ad300 mouse xenograft model at 3 mg/kg in combination with paclitaxel
Cayman Chemical NMS-P118, Purity: ≥98%, CAS: 1262417-51-5, 1 mg
A potent and selective PARP1 inhibitor; selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM); efficacious in mouse xenograft models of breast and pancreatic cancer
![AdipoGen VR23 [Proteasome Inhibitor] (1 mg)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502054066.PNG-250.jpg)
AdipoGen VR23 [Proteasome Inhibitor] (1 mg)
Chemical. CAS: 1624602-30-7. Formula: C19H16ClN5O6S. MW: 477.9. Synthetic. Potent selective and reversible chloroquine derivative 20S proteasome inhibitor (all proteolytic subunits). Targets the trypsin-like beta2 subunit of the constitutive 20S proteasome (IC50=1nM). Cross-reacts and inhibits the chymotrypsin-like beta5 subunit (IC50=50-100nM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=3µM). Anticancer compound effective in cell-based assays and against multiple myeloma and metastatic breast cancer in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, as well as in bortezomib-resistent multiple myeloma cells, but with minimal effects on non-cancerous cells.
Medchemexpress LLC AM-9747 | 2691869-82-4 | 99.76% | 466.46 | 250 MG
AM-9747 (compound 503) is a potent PRMT5 inhibitor with a Ki value of 0.06 nM. It shows antiproliferative activity against HCT116-MTAP null cells (IC50 0.026 μM) and HCT116-WT cells (IC50 0.068 μM) after 6 days.
- Potent PRMT5 inhibitor
- Antiproliferative activity
- High purity of 99.76%
Cayman Chemical (+)-N-3-Benzylnirvanol, Purity: ≥95%, CAS: 790676-40-3, 5 mg
An inhibitor of CYP2C19 (Ki = 0.25 µM); selective for CYP2C19 over CYP1A2, -2A6, -2C8, -2C9, -2D6, -2E1, and -3A4 at 1 µM and over CYP2B6 (IC50 = 58 µM)
Medchemexpress LLC RAGE antagonist peptide | 1092460-91-7 | 98.2% | 1272.55 | 100 MG
RAGE antagonist peptide | 1092460-91-7 | 98.2% | 1272.55 | 100 MG
Medchemexpress LLC [Gln8]-C517 (LH-RH), chicken | 47922-48-5 | 99.97% | 1154.23 | 100 MG
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide that stimulates the release of gonadotropins from the anterior pituitary, thereby regulating reproductive functions.
- Intended for research use only.
- Solid appearance.
- White to off-white color.
- Sequence: {pGLU}-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly.
- Soluble in H2O at 100 mg/mL (requires ultrasonic).
- Targets GnRH receptor.
- Involved in GPCR/G protein pathway.
Medchemexpress LLC FGF-8c Mouse His 100ug
FGF-8c Protein Mouse is an isoform of FGF-8 an essential factor during embryonic development involved in the progression of prostate cancer